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Hits:5607 , posted at 2020/3/30 13:19
Recently，CSBio has
completed the installation of the first Oligo DNA/RNA Synthesizer
apparatus in China
The CS-OLIGO-D from CSBio is a fullyautomated DNA/RNA oligonucleotide
synthesizers that can be used from research,process development and production.
This system is equipped with a reactionvessel that has 180° inversion
mixing, flow through, and reaction vesselrecirculation capabilities. This
allows for batch synthesis with high loadresin swelling, traditional flow
through DNA synthesis, and recirculation forRNA synthesis.
Device Application
The Device is used to develop new oligonucleotide drugs that can be
used as gene therapies for some rare diseases and diseases caused by viruses.
Principle of operation
Ourmixing is to suspend the resin in
the reaction solution with the resin floatingin the RV. With fully suspended
resin that is moving within solution, it willyield high reaction and washing
efficiency.
Key
System Operation
• Mixing
is performed by 180ºinversion with argon bubbling
either from the top or bottom of the reactionvessel.
•
The reaction vessel is anopen reactor made of borosilicate glass
• Flow
through utilized fordetritylation, inversion mixing is possible during flow
through.
• UV
detection fordetritylation
• Argon
line/reservoir purgingutilized to maintain inert atmosphere
• 8x
individual amiditepositions (more at request)
•
Circulation is possible withthe system
Evaluation
LCMS
Comparison
CSBio Introduction
CSBio is Global peptide company bringing more than 26 years of technical expertise into the peptide industry which cover three main categories of products and services:
1) peptide CDMO & CMO service -GMP and R&D peptide production, with API peptide production approved by USFDA.
2) Peptide Instrumentation - from R&D up to Large Scale Manufacturing-type synthesizer, Cleavage systems, PreHPLC system, Column packing equipment and peptide production technical support.
3) Peptide raw material -- High Quality Standard Grade and High Grade Fmoc-protected Amino Acid, peptide reagents, coupling reagents, resins and special reagents, supported by relevant validated QC data, stability data and DMF technical documents.
CSBio (Shanghai) Ltd.
China (Shanghai) Pilot Free Trade Zone, 85 Faladi Road, Building 2,Room 502 ,Shanghai 201210, China
Email:info@csbiochina.com
Tel:+8621-50781653/50781655
Fax:+8621-50781652/021-50781656
Website: www.csbiochina.com www.csbio.com
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Technical information